Plasminogen Deficiency

Laboratory Evaluation

In patients with lesions suspected to be ligneous, a plasminogen antigen and activity level should be obtained. As the majority of clinical lesions have been associated with type I deficiency, it is important to evaluate both assays to demonstrate a decreased plasminogen activity with concordant decrease in protein level. Plasminogen activity is measured with a chromogenic assay with a general normal range of 70-130%, while antigenic testing is commonly performed via immunologic assays with a normal reported range of approximately 6-25mg/dL.1 By the age of 1 year, the plasminogen levels have reached a stable level, and do not vary with age.32