Factor XI Deficiency

Medications/Treatment

Several possible treatments are available for FXI deficiency28. The pros and cons are shown in Table 1, and the treatment of specific clinical scenarios is considered in Table 2.

Click on table to enlarge.

Table1 Factor XI Deficiency

Table 2 Factor XI Deficiency

The first issue is to decide whether treatment is required. This decision will depend on the hemostatic challenge under consideration, the patient’s past medical history with interventions, if present, and to some extent on the level of deficiency24. Many women with severe FXI deficiency have given birth without treatment aimed at increasing the FXI level, but would not be eligible for spinal anaesthesia in these circumstances.